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The department of Chemical Process Research & Development (CPRD) focuses on the development of synthetic methodologies and processes for small molecules, oligonucleotides, peptides and other emerging modalities. In the group PRD (Process R& D) we currently have open positions for synthetic chemists with a passion for designing the best possible chemistry and processes.

Job description:

The API Process Research and Development (PRD) team generates creative and innovative ideas towards new synthetic routes and solutions that enable large scale manufacturing of target Active Pharmaceutical Ingredients. Our process chemists team up with engineers, analysts, crystallization-, and safety experts to design the best manufacturing process. These teams work closely together with the pilot plants and bridge with commercial production. New chemical processes are developed meeting stringent requirements concerning safety, environment, technology, economy, and quality. As a result of these endeavours, drug candidates are accelerated through the development pipeline by enabling sufficient supplies of active ingredient in support of clinical trials, registration and finally commercialization.

As a PRD scientist you will be responsible to develop the best possible process and to support the project during the different stages of development. You will be focusing on inventing new chemistry towards new Active Pharmaceutical Ingredients and translating this chemistry into a process that can be performed in a robust, sustainable and safe way in a large-scale manufacturing plant.

Experience and skills

• PhD in Organic chemistry; post-doc experience is a plus.
• Consistent track record of scientific excellence and successful research in organic chemistry supported by peer-reviewed publications.
• Passionate to work in the lab and able to perform chemical experiments in state-of-the-art chemical laboratories.
• Demonstrated creativity and innovation in problem solving.
• Excellent oral and written communication skills, fluent in English both verbal and in writing.
• Good soft skills, willing to challenge the status quo in a constructive manner suggesting alternative solutions for existing problems.
• We truly believe that the best science comes out of strong teamwork. Able and willing to work in a team with different backgrounds (education, gender, nationality, …) is a must!

Differentiating competencies

• Knowledge of automated synthesis approaches and lab reactors and/or high throughput experimentation set-ups.
• Expertise or an interest in handling large data sets, artificial intelligence, molecular modelling and machine learning.
• Process chemistry knowledge: scale-up and engineering aspects.
• Oligonucleotide synthesis, carbohydrate and phosphorus chemistry.
• Biocatalysis and transition metal catalysis.
• Flow, photo- and electrochemistry.

Our offer

• An exciting position in an international and dynamic environment with continuous learning and growth opportunities.
• An attractive remuneration package with additional benefit packages (for example hospital insurance, and other health care incentives).
• An inclusive team environment where diversity and different opinions are respected and valued, and the importance of a good work-life balance is recognized.