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Job Description:

The Bioanalytical Discovery and Development Sciences (BDDS) organization develops, validates, and conducts bioanalytical sample analysis across the entire J& J Innovative Medicines (JJIM) R& D portfolio from discovery through development. We are looking for an enthusiastic and dedicated Principal Scientist to design and perform all type of bioanalytical assays within BDDS for Johnson & Johnson discovery projects spanning all modalities and therapeutic areas. This laboratory-based position offers the opportunity to lead the development and implementation of innovative analytical methods using chromatographic techniques, immunoassays and mass spectrometry. If you are passionate about pushing the boundaries of analytical techniques and eager to make a significant impact in the field, we would love to hear from you!

Job Description

• Design, develop and qualify advanced analytical methods for the quantification of drugs and biomarkers (small and large molecules) in different types of (biological) matrices according to company standards.
• Take the lead in setting bioanalytical strategies for the different research programs according to the required deliverables and translate research questions in operational lab experimental work.
• Perform project activities as individual contributor through hands-on data generation and use advanced software tools for data analysis.
• Report and present data in scientific and cross-functional meetings and write technical reports and peer reviewed manuscripts.
• Evaluate current bioanalytical methods and processes and critically perform optimization and troubleshooting when needed.
• Explore automation and software related solutions to increase workflows efficiency.
• Coach and train junior colleagues in techniques, processes and responsibilities with a team player attitude.
• Collaborate closely with other internal or external research groups and cross-functional teams, to propose and explore innovative solutions.
• Work in a discovery fast-paced environment with a high level of autonomy.

Qualifications

• A Ph.D. in Chemistry, Biochemistry, Pharmaceutical Sciences or related discipline with a minimum of 4 years of relevant industry experience or a Master’s with a minimum of 6 years of relevant industry experience.
• Proven proficiency in protein analysis using Ligand Binding Assays (e.g. MSD platform) as well as LC-MS.
• Hands-on experience in the use of nano and micro liquid chromatography coupled to mass spectrometry is required. Practical knowledge and expertise in therapeutic peptide analysis and proteomics is preferred.
• Experience in different types of sample preparation techniques (SPE, LLE, IMC...) and working in an industrial quality environment.
• Strong data science skills, such as Excel macros, R programming and statistical analysis is preferred.
• Ability to work on several projects and assignments at the same time, with appropriate prioritization.
• Excellent English communication skills, both written and spoken.