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Job Description:

We are searching for the best talent for our Senior Scientist, Biologics position, located in Spring House, PA.

About Innovative Medicine

Our expertise in Innovative Medicine is informed and inspired by patients, whose insights fuel our science-based advancements. Visionaries like you work on teams that save lives by developing the medicines of tomorrow.

Join us in developing treatments, finding cures, and pioneering the path from lab to life while championing patients every step of the way.

Learn more at https: //www.jnj.com/innovative-medicine

Purpose:

We are seeking an accomplished Sr. Scientist with deep expertise in higher order structure (HOS) characterization of Antibody-Drug Conjugates (ADCs) to join our Biophysics team. The ideal candidate will play a pivotal role in supporting the structural integrity assessment of ADCs in drug discovery. The Scientist will lead the development and application of advanced biophysical and structural methodologies to understand conjugation effects on antibody structure, stability, and function.

You will be responsible to:

• Serve as a HOS subject matter expert (SME) of ADCs, designing and performing structural studies to assess: 1) impact of drug conjugation on antibody folding, domain structure, and inter-chain interactions. 2) conformational changes, aggregation propensity, and stability profiles.
• Develop, optimize, and interpret data from advanced HOS analytical techniques.
• Lead training initiatives on HOS techniques and ADC-specific structural characterization challenges including forced degradation studies and linker stability.
• Continuously evaluate new biophysical technologies and workflows for high-resolution structural assessment of complex ADC molecules and new modalities.
• Apply the workflows to study antibody conformational stability, domain interactions, and aggregation mechanisms under formulation and stress conditions.
• Collaborate with cross-functional and multidisciplinary teams in Formulation Development, Protein Engineering, Data Science, MS characterization and Binding group.
• Analyze complex datasets using advanced analytical and computational tools.
• Present research findings at internal and external scientific meetings and symposiums.

Qualifications

Education:

• M.Sc with 5+ years of work experience OR Ph.D and 0-3+ years of work experience in Biophysics or Biochemistry, Structural biology, Analytical chemistry, or a closely related field is required.

Experience and Skills:

Required:

• Proven experience with HOS characterization of ADCs, including an understanding of drug-to-antibody ratio (DAR), stability, and structural heterogeneity.
• Experience with biophysical techniques (e.g., DSC, DLS, DSF, and HPLC) and strong background in spectroscopy (fluorescence, UV-Vis, Infrared, and NMR), light scattering, calorimetry, and computational modeling.
• Excellent problem-solving skills and a strong publication record.

Preferred:

• Experience with data analysis software, programming languages (e.g., Python, AI/ML-based programming), and simulation tools (multi-step binding affinity or kinetics modelling, structural modeling tools such as PyMOL, MOE, Schrodinger, Rosetta etc).
• Basic knowledge and applied understanding of kinetics and thermodynamics properties and their applications in characterizing proteins’ structure and dynamics.

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson & Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please contact us via https: //www.jnj.com/contact-us/careers or contact AskGS to be directed to your accommodation resource.

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