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We are searching for the best talent for a Principal Scientist, Radiochemist (Discovery Chemistry) to be onsite in Spring House, PA.

Purpose:
The Radiochemist will be a technical expert in the discovery and development of radiolabeling chemistries that produce targeted radiotherapeutics. They will work independently in collaboration with cross functional discovery teams, early and late development organizations, and external partners (C(D)MOs) to facilitate the successful discovery and development of next-generation Radiotherapeutics, and radiopharmaceutical manufacturing processes for clinical and commercial development.

You will be responsible for:
• Make significant contributions at the program team level around radiopharmaceutical design based on the target and develop new radiolabeling methodologies and formulations (to prevent/minimize radiolysis) for discovery and preclinical stage programs.
• Evaluate novel chelator and linker combinations that incorporate therapeutic radioisotopes to drive optimal biophysical and stability properties.
• Work closely with discovery biology, bioconjugation and PET radiochemistry teams to assist in the development of preclinical imaging tracers and companion PET diagnostics.
• Develop novel analytical methods that are both suitable and optimized for different modality-based targeting vectors/delivery vehicles.
• Support the filing of regulatory documents (INDs, ANDAs) for the use of the novel radiopharmaceutical and author research and development reports, manuscripts for publications and assist in patent applications.
• Lead discussions in the transfer of radiochemistry technology, analytical procedures and proprietary techniques to internal and external clinical development manufacturing operations.
• Instill a strong radiation safety culture and occasionally consult to clinical teams.
• Prepare and deliver presentations to internal and external teams.

Qualifications / Requirements:

Education:
• Bachelor’s degree required
• Master’s degree or PhD highly preferred

Required:
• Minimum of 6 years experience in radiochemistry development, manufacturing of radiotherapies, and organic chemistry.
• Skilled in leading teams and discussions during the early stages of development to make sure that molecular features and experimental designs are appropriate for their goals.
• Hands-on experience with therapeutic radioisotopes (e.g. Ac-225, Lu-177, Cu-67, or Pb-212)
• Experienced in quality control testing of Radiotherapeutics. Hands-on experience with radio-HPLC, radio-ITLC and/or GC.
• Knowledge of environmental health and radioprotection requirements
• Proven ability to work independently with strong organization and communication skills
• Demonstrated ability to successfully prioritize projects and manage timelines in a fast-paced environment
• Position will require up to 10-15% of travel

Preferred:
• Experience contributing to the early planning of CMC (Chemistry, Manufacturing, and Controls) strategy, including important radiochemical features for a successful product launch
• Functional knowledge of GMPs and applicable FDA, EMA, Health Canada, USP, ICH and PDA guidelines

Johnson & Johnson is an Equal Opportunity Employer. All qualified applicants will receive consideration for employment without regard to race, color, religion, sex, sexual orientation, gender identity, age, national origin, disability, protected veteran status or other characteristics protected by federal, state or local law. We actively seek qualified candidates who are protected veterans and individuals with disabilities as defined under VEVRAA and Section 503 of the Rehabilitation Act.

Johnson and Johnson is committed to providing an interview process that is inclusive of our applicants’ needs. If you are an individual with a disability and would like to request an accommodation, please email the Employee Health Support Center (ra-employeehealthsup@its.jnj.com) or contact AskGS to be directed to your accommodation resource.

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