At Johnson & Johnson, we believe health is everything. Our strength in healthcare innovation empowers us to build a world where complex diseases are prevented, treated, and cured, where treatments are smarter and less invasive, and solutions are personal. Through our expertise in Innovative Medicine and MedTech, we are uniquely positioned to innovate across the full spectrum of healthcare solutions today to deliver the breakthroughs of tomorrow, and profoundly impact health for humanity. Learn more at https: //www.jnj.com

Job Function:

Job Sub Function:

Job Category:

All Job Posting Locations:

Job Description:

ROLE OVERVIEW:

Johnson & Johnson is recruiting for a Vice President, Head of Experimental Medicine, Neuroscience to be based at one of our sites in Titusville, NJ; Cambridge, MA; Spring House, PA; La Jolla, CA.

The Vice President, Head of Experimental Medicine, Neuroscience (NS) TA, reports to the Global Head of Clinical Development, NS and is accountable for strategic leadership and oversight of translational medicine (including experimental science), and all clinical development activities from LO to end of Phase 2a.

The Head of Experimental Medicine will lead a team of talented and experienced MD/PhD clinicians and scientists focused on disease understanding and experimental medicine encompassing all disease areas within the current remit of the TA (Neuropsychiatry, Neurodegeneration, Ophthalmology). In addition, this position will be responsible for the early development portfolio across Neuroscience and provide line management for CDTL’s leading early development programs. A key operating principle for this team within the Neuroscience Therapeutic Area is to enable a culture of integrated Discovery and Development. Excellence in experimental medicine-based early human studies that confirm mechanism of action, pharmacology and initial assessments of efficacy is viewed as essential to this organization.

RESPONSIBILITIES:

• Collaborates with the Neuroscience TA leadership to develop comprehensive clinical and scientific de-risking strategies for the drug candidate(s) to move quickly into the late stage of clinical development.
• Works with the DAS Heads and NS functional leads to define the clinical translational strategy and delivery plan well in advance of IND submission to ensure program readiness and success.
• Partners closely with the Precision Measures organization (particularly the Strategy Implementation Leader and Translational Program leader) to develop and drive experimental science in support of TA strategy.
• Drives the development and implementation of compound early phase/translational medicine strategy, including defining and communicating key strategic questions and recommendations regarding study design, patient selection and precision approaches, endpoints (including novel endpoints), safety evaluation, dose, pharmacology, and PD biomarkers through the early Compound Development Teams (CDTs).
• Ensures early phase CDTs work closely with discovery, biomarkers, data science and translation teams to align preclinical and clinical biomarker strategies, including the identification and validation of novel endpoints (e.g., biomarkers, intermediate clinical endpoints, digital COAs) to support patient stratification and rapid decision making.
• Provides clinical and scientific input into the overarching Translational and Precision Medicine Strategy for assets and disease areas in the NS (TA), leads clinical translational forum activities and represents neuroscience on the First in Human Committee
• As a member of the Development Leadership Team, actively contributes to the governance and strategy of the TA, including programs, people, and budget.
• Provide leadership to Early Development group; ensuring resources, personnel, and expertise are appropriately prioritized and deployed.
• Provides technical and strategic expertise to ensure ED plans and studies are conceived and executed with a focus on quality, speed, and cost-effectiveness.
• Ensures appropriate data interpretation, reporting and incorporation into the clinical sections of key documents, including regulatory documents (e.g., IND) and Investigator Brochures
• Manages and develop staff to optimize performance: sets performance goals and monitor results and provides timely performance feedback.
• Contribute to clinical SOP development, adoption, adherence, and improvement.
• Review and approve abstracts, posters, and presentations for scientific meetings and manuscripts for publication.
• Develop relationships with key stakeholders externally and with internal leaders and other departments to help shape and define future directions and projects.
  Contribute to due diligence and evaluation of new assets for development directly or through appropriate delegation.
• Creates a purpose driven culture in which decisions and actions are strategically informed by patient, customer and employee needs by aligning Johnson & Johnson’s Credo and Leadership Imperatives with the strategies and goals of the team and enterprise.
• Manages multiple cross functional early phase Compound Development Team Leaders (usually at the Senior Director level), and senior individual contributors (MD Clinical Leads and Study Responsible Physicians).
• This position will typically have 4-6 direct reports

Qualifications - External