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The Position

We are looking for a highly motivated and talented Postdoctoral Fellow (m/f/d) to join our Discovery Sciences team. In this role you will be at the forefront of Science, developing a system to investigate molecular rules of immune recognition, particularly TCR/pMHC interactions, to ultimately develop predictive models of TCR/pMHC specificity.

Your responsibilities will encompass the design, execution, and analysis of wet-lab experiments focused on investigating the molecular determinants of TCR-pMHC recognition, as well as the implementation of single cell sequencing experiments.

This position is embedded within the Discovery Sciences Chapter at Roche Diagnostics GmbH. As part of the In Silico Biomarker and Technology Subchapter, you will join a high-impact team of researchers dedicated to pioneering next-generation diagnostic solutions.

Our culture is defined by trust, transparency, and a strong collaborative spirit. We are looking for a proactive colleague who balances independent critical thinking with team spirit and the flexibility to collaborate across diverse departments and interdisciplinary teams.

Your tasks

• Independently develop and refine a platform for sequencing pMHC-specific TCRs, including T-cell stimulation and culture protocols.
• Design pMHC libraries and generate necessary plasmids/vectors; optimize viral titers and transduction yields for transient transfection and stable cell line generation.
• Perform rigorous quality control using fundamental assays such as ELISA, qPCR, and flow cytometry.
• Implement and execute high-throughput sequencing of immune repertoires and analyze/support analysis of complex experimental and bioinformatic datasets.
• Partner with bioinformatics, assay development, and sequencing teams to ensure the system’s applicability for Diagnostic platforms.
• Drive interdisciplinary meetings to share data, leverage expertise across functions, and contribute to the broader Diagnostics strategy.
• Document findings for patent filings and present research in stakeholder meetings, scientific journals, and international conferences.

Your profile

• You have successfully completed a PhD in Immunology, Molecular Biology, or a related field with 3+ years of research experience and a strong track record of peer-reviewed publications.
• You have deep expertise in T cell immunology and cellular and molecular laboratory techniques, such as cell line and primary cell culture, transient and stable transfections, flow cytometry, ELISA/IGRA, and qPCR.
• You possess end-to-end proficiency in single-cell sequencing - from library preparation, initial data handling and exploratory analysis using R, Python, bash to comprehending bioinformatic pipelines.
• You have a strong foundation in statistical concepts and testing as applied to complex biological datasets.
• Your hands on experience with peptide or antibody display technologies is considered a plus
• You are goal-oriented and eager to establish new wet-lab techniques
• Your personal drive and your ability to learn and take over responsibility is a key value for us.
• You possess excellent communication skills and fluency in English

When does it start?

This position will be filled with effect September 2026 and is limited to 2 years.

Have we aroused your interest?

# If we are convinced, a telephone or virtual interview will take place
# If you also manage to convince us here, the last step is an interview and presentation in the Penzberg area

Your application

Please submit your application by sending an updated CV (including publication list and references) together with your latest certificates. Before sending your application, please note that no further documents can be added subsequently.

We are looking forward to your application!

Your contact to us! With people. For people.

Do you need further support?

Please have a look at our FAQs, you will find them via https: //careers.roche.com/global/en/faq.

Who we are

A healthier future drives us to innovate. Together, more than 100’000 employees across the globe are dedicated to advance science, ensuring everyone has access to healthcare today and for generations to come. Our efforts result in more than 26 million people treated with our medicines and over 30 billion tests conducted using our Diagnostics products. We empower each other to explore new possibilities, foster creativity, and keep our ambitions high, so we can deliver life-changing healthcare solutions that make a global impact.

Let’s build a healthier future, together.